Beyond Inhibition: Targeted Protein Degradation Unlocks New Aven
Beyond Inhibition: Targeted Protein Degradation Unlocks New Avenues for Drug Discovery Targeted protein degradation (TPD) represents a novel therapeutic strategy for historically challenging disease-causing proteins. The concept of proteolysis-targeting chimera (PROTAC) molecules, leveraging the ubiquitin-proteasome system for targeted degradation, emerged two decades ago. Since then, TPD has transitioned from academic research to a robust industry…